Figure 2. siG12D drug covers the entire tumor tissue within one week.

Subcutaneous tumors of pancreatic PancO2 origin were treated with empty-LODER^TM or LODER^TM containing 5μg siG12D. Seven days post-implantation mice were sacrificed, tumor tissue was formalin-fixed, paraffin embedded and cut to slices of 5μm. A. The graph depicts relative amounts of antisense siG12D strand, measured by Relative Quantitative Real-Time PCR, at certain distances from the LODER^TM border. The results were normalized to RNU6 and calibrated to untreated control. B. Representative tumor tissue, H&E stained, seven days post implantation.