Table 2.
Summary estimates for intraocular pressure at 3 months derived from network meta-analysis of 114 trials*
| Placebo | −2.52 (−4.11;−0.94) | −3.59 (−4.29;−2.89) | −2.24 (−2.88;−1.59) | −3.44 (−4.46;−2.42) | −4.51 (−5.24;−3.8) | −3.7 (−4.24;−3.16) | −2.56 (−3.62;−1.52) | −2.42 (−3.23;−1.62) | −2.49 (−3.13;−1.85) | −5.61 (−6.29;−4.94) | −4.85 (−5.46;−4.24) | −4.83 (−5.54;−4.12) | −4.37 (−5.83;−2.94) | −1.91 (−2.67;−1.15) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2.52 (0.94;4.11) |
Apraclonidine | −1.08 (−2.65;0.52) |
0.28 (−1.29;1.87) |
−0.92 (−2.64;0.81) |
−2 (−3.58;−0.39) |
−1.18 (−2.67;0.31) |
−0.05 (−1.81;1.72) |
0.09 (−1.55;1.75) |
0.03 (−1.54;1.62) |
−3.1 (−4.65;−1.53) |
−2.33 (−3.85;−0.79) |
−2.31 (−3.88;−0.73) |
−1.85 (−3.85;0.15) |
0.61 (−0.99;2.23) |
| 3.59 (2.89;4.29) |
1.08 (−0.52;2.65) |
Brimonidine | 1.35 (0.67;2.04) |
0.15 (−0.87;1.17) |
−0.92 (−1.69;−0.16) |
−0.11 (−0.64;0.42) |
1.03 (−0.05;2.1) |
1.17 (0.4;1.92) |
1.1 (0.4;1.8) |
−2.02 (−2.69;−1.35) |
−1.25 (−1.8;−0.72) |
−1.24 (−1.92;−0.55) |
−0.78 (−2.23;0.65) |
1.69 (0.92;2.45) |
| 2.24 (1.59;2.88) |
−0.28 (−1.87;1.29) |
−1.35 (−2.04;−0.67) |
Betaxolol | −1.2 (−2.21;−0.19) |
−2.28 (−3.01;−1.55) |
−1.46 (−1.99;−0.94) |
−0.32 (−1.38;0.72) |
−0.18 (−1.03;0.65) |
−0.25 (−0.91;0.4) |
−3.37 (−4.06;−2.7) |
−2.61 (−3.2;−2.02) |
−2.59 (−3.3;−1.89) |
−2.13 (−3.58;−0.7) |
0.33 (−0.42;1.08) |
| 3.44 (2.42;4.46) |
0.92 (−0.81;2.64) |
−0.15 (−1.17;0.87) |
1.2 (0.19;2.21) |
Carteolol | −1.08 (−2.07;−0.09) |
−0.26 (−1.14;0.61) |
0.88 (−0.42;2.16) |
1.02 (−0.11;2.14) |
0.95 (−0.07;1.96) |
−2.17 (−3.16;−1.18) |
−1.41 (−2.35;−0.47) |
−1.39 (−2.4;−0.38) |
−0.93 (−2.54;0.66) |
1.53 (0.47;2.59) |
| 4.51 (3.8;5.24) |
2 (0.39;3.58) |
0.92 (0.16;1.69) |
2.28 (1.55;3.01) |
1.08 (0.09;2.07) |
Levobunolol | 0.81 (0.25;1.38) |
1.95 (0.86;3.04) |
2.09 (1.2;2.99) |
2.03 (1.28;2.77) |
−1.1 (−1.83;−0.36) |
−0.33 (−0.99;0.33) |
−0.31 (−1.06;0.44) |
0.14 (−1.32;1.6) |
2.61 (1.79;3.43) |
| 3.7 (3.16;4.24) |
1.18 (−0.31;2.67) |
0.11 (−0.42;0.64) |
1.46 (0.94;1.99) |
0.26 (−0.61;1.14) |
−0.81 (−1.38;−0.25) |
Timolol | 1.14 (0.19;2.07) |
1.28 (0.56;1.99) |
1.21 (0.69;1.73) |
−1.91 (−2.38;−1.44) |
−1.15 (−1.5;−0.79) |
−1.13 (−1.63;−0.63) |
−0.67 (−2.02;0.67) |
1.79 (1.18;2.41) |
| 2.56 (1.52;3.62) |
0.05 (−1.72;1.81) |
−1.03 (−2.1;0.05) |
0.32 (−0.72;1.38) |
−0.88 (−2.16;0.42) |
−1.95 (−3.04;−0.86) |
−1.14 (−2.07;−0.19) |
Levobetaxolol | 0.14 (−1.03;1.32) |
0.07 (−0.99;1.14) |
−3.05 (−4.09;−1.99) |
−2.28 (−3.28;−1.27) |
−2.27 (−3.32;−1.19) |
−1.81 (−3.45;−0.18) |
0.66 (−0.45;1.78) |
| 2.42 (1.62;3.23) |
−0.09 (−1.75;1.55) |
−1.17 (−1.92;−0.4) |
0.18 (−0.65;1.03) |
−1.02 (−2.14;0.11) |
−2.09 (−2.99;−1.2) |
−1.28 (−1.99;−0.56) |
−0.14 (−1.32;1.03) |
Brinzolamide | −0.07 (−0.85;0.71) |
−3.19 (−4.03;−2.36) |
−2.42 (−3.18;−1.66) |
−2.41 (−3.26;−1.55) |
−1.95 (−3.47;−0.44) |
0.52 (−0.39;1.43) |
| 2.49 (1.85;3.13) |
−0.03 (−1.62;1.54) |
−1.1 (−1.8;−0.4) |
0.25 (−0.4;0.91) |
−0.95 (−1.96;0.07) |
−2.03 (−2.77;−1.28) |
−1.21 (−1.73;−0.69) |
−0.07 (−1.14;0.99) |
0.07 (−0.71;0.85) |
Dorzolamide | −3.12 (−3.8;−2.44) |
−2.36 (−2.95;−1.76) |
−2.34 (−3.05;−1.63) |
−1.88 (−3.32;−0.45) |
0.58 (−0.19;1.36) |
| 5.61 (4.94;6.29) |
3.1 (1.53;4.65) |
2.02 (1.35;2.69) |
3.37 (2.7;4.06) |
2.17 (1.18;3.16) |
1.1 (0.36;1.83) |
1.91 (1.44;2.38) |
3.05 (1.99;4.09) |
3.19 (2.36;4.03) |
3.12 (2.44;3.8) |
Bimatoprost | 0.77 (0.27;1.26) |
0.78 (0.26;1.3) |
1.24 (−0.18;2.65) |
3.71 (2.97;4.44) |
| 4.85 (4.24;5.46) |
2.33 (0.79;3.85) |
1.25 (0.72;1.8) |
2.61 (2.02;3.2) |
1.41 (0.47;2.35) |
0.33 (−0.33;0.99) |
1.15 (0.79;1.5) |
2.28 (1.27;3.28) |
2.42 (1.66;3.18) |
2.36 (1.76;2.95) |
−0.77 (−1.26;−0.27) |
Latanoprost | 0.02 (−0.5;0.53) |
0.48 (−0.91;1.83) |
2.94 (2.33;3.55) |
| 4.83 (4.12;5.54) |
2.31 (0.73;3.88) |
1.24 (0.55;1.92) |
2.59 (1.89;3.3) |
1.39 (0.38;2.4) |
0.31 (−0.44;1.06) |
1.13 (0.63;1.63) |
2.27 (1.19;3.32) |
2.41 (1.55;3.26) |
2.34 (1.63;3.05) |
−0.78 (−1.3;−0.26) |
−0.02 (−0.53;0.5) |
Travoprost | 0.46 (−0.98;1.87) |
2.92 (2.17;3.68) |
| 4.37 (2.94;5.83) |
1.85 (−0.15;3.85) |
0.78 (−0.65;2.23) |
2.13 (0.7;3.58) |
0.93 (−0.66;2.54) |
−0.14 (−1.6;1.32) |
0.67 (−0.67;2.02) |
1.81 (0.18;3.45) |
1.95 (0.44;3.47) |
1.88 (0.45;3.32) |
−1.24 (−2.65;0.18) |
−0.48 (−1.83;0.91) |
−0.46 (−1.87;0.98) |
Tafluprost | 2.46 (1.01;3.95) |
| 1.91 (1.15;2.67) |
−0.61 (−2.23;0.99) |
−1.69 (−2.45;−0.92) |
−0.33 (−1.08;0.42) |
−1.53 (−2.59;−0.47) |
−2.61 (−3.43;−1.79) |
−1.79 (−2.41;−1.18) |
−0.66 (−1.78;0.45) |
−0.52 (−1.43;0.39) |
−0.58 (−1.36;0.19) |
−3.71 (−4.44;−2.97) |
−2.94 (−3.55;−2.33) |
−2.92 (−3.68;−2.17) |
−2.46 (−3.95;−1.01) |
Unoprostone |
*
Posterior means (95% Bayesian credible intervals) are calculated by column - row under the Lu and Ades homogeneous random effects model assuming consistency (22). Mean difference < 0 favors the drug in the column; mean difference > 0 favors the drug in the row.
Color coding:
