Table 4.
Performance Comparison of New GFR-Estimating Equation to CKD-EPI Cystatin C and CKD-EPI Creatinine-Cystatin C Equations in All 103 Subjects with Cirrhosis and Stratified by Type of Ascites
| CKD-EPI Cystatin C Equation (2012) |
CKD-EPI Creatinine-Cystatin C Equation (2012) |
New GFR-Estimating Equation Developed from Subjects with Cirrhosis |
|||||
|---|---|---|---|---|---|---|---|
| All Subjects | Bias (95% CI) | 7.43 | (2.27 – 12.58) | −1.14 | (−5.72 – 3.44) | 2.54 | (−1.94 – 7.01) |
| P value† | 0.001 | 0.0001 | |||||
| Precision (95% CI)* | 26.37 | (23.20 – 30.56) | 23.44 | (20.61 – 27.16) | 22.89 | (20.14 – 26.53) | |
| P Value† | 0.020 | 0.589 | |||||
| Accuracy (95% CI)* | 27.27 | (21.22 – 32.21) | 23.35 | (18.13 – 27.60) | 22.92 | (17.12 – 27.53) | |
| P Value† | 0.004 | 0.691 | |||||
| Pre-Ascites | Bias (95% CI) | 18.20 | (7.70 – 28.70) | 7.49 | (−2.43 – 17.42) | 12.03 | (1.73 – 22.32) |
| P value† | 0.019 | 0.012 | |||||
| Precision (95% CI)* | 29.12 | (23.34 – 38.71) | 27.53 | (22.07 – 36.60) | 28.55 | (22.89 – 37.96) | |
| P Value† | 0.830 | 0.634 | |||||
| Accuracy (95% CI)* | 33.95 | (17.52 – 44.70) | 28.12 | (13.25 – 37.49) | 30.57 | (15.96 – 40.18) | |
| P Value† | 0.196 | 0.275 | |||||
| Diuretic-Sensitive Ascites | Bias (95% CI) | 1.97 | (−4.65 – 8.59) | −5.84 | (−11.64 – −0.03) | −1.11 | (−6.98 – 4.76) |
| P value† | 0.236 | 0.006 | |||||
| Precision (95% CI)* | 20.14 | (16.42 – 26.06) | 17.66 | (14.40 – 22.85) | 17.86 | (14.56 – 23.11) | |
| P Value† | 0.406 | 0.904 | |||||
| Accuracy (95% CI)* | 19.97 | (14.84 – 24.03) | 18.38 | (12.66 – 22.71) | 17.66 | (11.42 – 22.21) | |
| P Value† | 0.423 | 0.639 | |||||
| Diuretic-Refractory Ascites | Bias (95% CI) | 3.26 | (−6.49 – 13.02) | −4.11 | (−12.39 – 4.18) | −2.46 | (−9.38 – 4.45) |
| P value† | 0.040 | 0.263 | |||||
| Precision (95% CI)* | 27.52 | (22.13 – 36.40) | 23.36 | (18.79 – 30.90) | 19.51 | (15.69 – 25.80) | |
| P Value† | 0.003 | 0.002 | |||||
| Accuracy (95% CI)* | 27.30 | (18.76 – 33.74) | 23.37 | (16.13 – 28.84) | 19.36 | (11.52 – 24.84) | |
| P Value† | 0.003 | 0.004 | |||||
Difference score for each subject=mGFR-eGFR by CKD-EPI cystatin C, CKD-EPI creatinine-cystatin C and new GFR-estimating equations
Bias=Mean of the difference scores
Precision=Standard deviation of the difference scores
Accuracy=Root mean squared error (RMSE)
Lower values of precision and accuracy indicate higher precision and higher accuracy, respectively
P values compare the performance of CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C equations to new GFR-estimating equation. P-values reported for bias reflect difference in the location of bias, not the magnitude of bias
CI=Confidence interval