Table 5.
Performance Comparison of New GFR Model to CKD-EPI Cystatin C and CKD-EPI Creatinine-Cystatin C Equations in All 103 Subjects with Cirrhosis and Stratified by Level of mGFR
| CKD-EPI Cystatin C Equation (2012) |
CKD-EPI Creatinine-Cystatin C Equation (2012) |
New GFR-Estimating Equation Developed from Subjects with Cirrhosis |
|||||
|---|---|---|---|---|---|---|---|
|
mGFR ≥ 60 ml/min/1.73m2 |
Bias (95% CI) | 10.02 | (2.77 – 17.27) | 1.14 | (−5.22 – 7.50) | 6.94 | (0.83 – 13.05) |
| P value† | 0.127 | <0.0001 | |||||
| Precision (95% CI)* | 30.18 | (25.85 – 36.27) | 26.47 | (22.67 – 31.81) | 25.43 | (21.78 – 30.55) | |
| P Value† | 0.014 | 0.426 | |||||
| Accuracy (95% CI)* | 31.60 | (23.93 – 37.73) | 26.31 | (19.64 – 31.59) | 26.18 | (18.76 – 31.91) | |
| P Value† | 0.004 | 0.927 | |||||
|
mGFR < 60 ml/min/1.73m2 |
Bias (95% CI) | 2.15 | (−3.14 – 7.44) | −5.78 | (−10.96 – −0.59) | −6.39 | (−10.88 – −1.90) |
| P value† | <0.0001 | 0.503 | |||||
| Precision (95% CI)* | 15.16 | (12.23 – 19.96) | 14.85 | (11.98 – 19.55) | 12.86 | (10.37 – 16.93) | |
| P Value† | 0.240 | 0.030 | |||||
| Accuracy (95% CI)* | 15.09 | (10.58 – 18.54) | 15.73 | (7.11 – 21.07) | 14.19 | (5.40 – 19.33) | |
| P Value† | 0.699 | 0.125 | |||||
Difference score for each subject=mGFR-eGFR by CKD-EPI cystatin C, CKD-EPI creatinine-cystatin C and new GFR-estimating equations
Bias=Mean of the difference scores
Precision=Standard deviation of the difference scores
Accuracy=Root mean squared error (RMSE)
Lower values of precision and accuracy indicate higher precision and higher accuracy, respectively
P values compare the performance of CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C equations to new GFR-estimating equation. P-values reported for bias reflect difference in the location of bias, not the magnitude of bias
CI=Confidence interval