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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Oncogene. 2015 Jun 29;35(12):1541–1553. doi: 10.1038/onc.2015.219

Figure 5. YAP knock-down sensitizes T24 cells to in vivo cisplatin anti-tumor activity.

Figure 5

A. NSshRNA or YAPshRNA expressing pGIPZ lentiviral vector infected T24 cells (5×106) were injected subcutaneously in SCID mice (6 or 7/group). Randomized mice were treated weekly with 0.9% NaCl solution (vehicle) or6 mg/kg CDDP i.p., for one month. Plot shows mean end-of-treatment tumor weight± SE. ANOVA p= 0.0461. B. Immunohistochemical staining for YAP, Ki67, phosphorylated ATM, and H2A.X in tumor tissues from the experiment described in panel A. Plots show blinded fashion quantification of percentage positive nuclei as mean ± SD. C. Ki67, D. phosphorylated ATM, E. phosphorylated H2A.X. Scale bar: 50 μm.*p <0.05, **p <0.01, ***p <0.001, n.s. non-significant, using two tailed t-test analysis.