Figure 6.

Similarity in the Pattern of Genome-wide Changes Induced by HU Treatment and Disruption of fancj or wrn/blm

(A) Up- and downregulated genes in HU-treated cells are shown.

(B) Overlap in genes dysregulated in HU-treated cells, fancj cells, and wrn/blm cells. (Left) Venn diagram shows the number of genes in each set. (Right) Venn diagram shows the percentage of genes in each overlap whose expression changes in the same direction. The p value was calculated with Fisher’s hypergeometric distribution.

(C) Correlation of magnitude and direction of change in expression between fancj, wrn/blm mutants and HU-treated wild-type cells.