Table 2.
Outcomes among all patients
| Variable | Metoclopramide + diphenhydramine | Metoclopramide + placebo | Difference (95%CI) |
|---|---|---|---|
| Improvement in 0–10 NRS pain score between baseline and one hour | 5.1 (n=104) | 4.8 (n=101)* | 0.3 (−0.6, 1.1) |
| Required rescue medication in ED | 31/104 (30%) | 40/104 (38%) | 9% (−4, 21%) |
| Sustained headache freedom1 | 17/101 (17%) | 14/102 (14%) | 3% (−7, 13%) |
| Want same med again2 | 84/99 (85%) | 77/102 (76%) | 9% (−2, 20%) |
| Functional impairment at one hour Unable to perform usual activities3 |
27/103 (26%)* | 30/98 (31%)* | 4% (−8, 17%) |
1
Achieved a headache level of “none” in the ED and maintained a level of “none” without the use of rescue medication for 48 hours. Patients who required rescue medication were considered outcome failures.
2
At the 48 hour follow-up telephone call patients were asked if they wished to receive the same medication during a subsequent migraine visit to the ED.
3
Patients who responded “I can’t get out of bed” and “I’d have a great deal of difficulty doing what I usually do” are included in the numerator. Patients who responded “I can do my normal activities” and “I’d have a little bit of difficulty doing what I usually do” are not included in the numerator.
*
Missing data when patient did not/could not answer the question