Table 2A.
Heritability Estimates by Cohort and diagnostic subgroup
| Total: Cases & Controls (N) | Cases: Path (N) | Cases: Clinical (N) | Cohort | Imputation Status: 107,447 Genotyped SNPs / 11,138,628 Imputed SNPs | Heritability | Standard Error | 95% Confidence Interval (Percentage Heritability) | P-value |
|---|---|---|---|---|---|---|---|---|
| 1252 | 28 | 258 | N.EU All | Genotyped | 0.1067 | 0.0435 | 2.13–19.21% | 0.007724 |
| Imputed | 0.0563 | 0.0346 | 0–12.42% | 0.04445 | ||||
| 1418 | 14 | 220 | S.EU All | Genotyped | 0.1902 | 0.0506 | 9.09–28.95% | 7.903e–05 |
| Imputed | 0.0918 | 0.0423 | 0.88–17.48% | 0.01439 | ||||
| 920 | 108 | 19 | US All | Genotyped | 0.06652 | 0.0941 | 0–25.10% | 0.2399 |
| Imputed | 0.0210 | 0.0742 | 0–16.65% | 0.3858 | ||||
| 1183 | 141 | 97 | UK All | Genotyped | 0.0000 | 0.0545 | 0–9.33% | 0.5 |
| Imputed | 0.0026 | 0.0463 | 0–7.63% | 0.4793 | ||||
| 4784 | 291 | 616 | All Pooled | Genotyped | 0.0490 | 0.0139 | 2.1–7.63% | 0.0001796 |
| Imputed | 0.0437 | 0.0116 | 2.09–6.65% | 3.252e–05 | ||||
| Cohort Meta- Analysis Random Effects Model | Genotyped I^2 = 5.1% |
0.0962 | 0.0424 | 1.32–17.94% | 0.0232 | |||
| Imputed I^2 = 0% |
0.0506 | 0.0221 | 0.72–9.40% | 0.0223 |