Table 2B.
Clinical Cohorts
| Total: Cases & Controls (N) | Cases: Path (N) | Cases: Clinical (N) | Cohort | Imputation Status: 107,447 Genotyped SNPs / 11,138,628 Imputed SNPs | Heritability | Standard Error | 95% Confidence Interval (Percentage Heritability) | P-value |
|---|---|---|---|---|---|---|---|---|
| 1224 | 0 | 258 | N.EU Clinical | Genotyped | 0.1184 | 0.0461 | 2.81–20.89% | 0.005081 |
| Imputed | 0.0658 | 0.0369 | 0–13.83% | 0.03057 | ||||
| 1404 | 0 | 220 | S.EU Clinical | Genotyped | 0.1977 | 0.0536 | 9.27–30.29% | 0.0001884 |
| Imputed | 0.0791 | 0.0446 | 0–16.67% | 0.03743 | ||||
| 812 | 0 | 19 | US Clinical | Genotyped | 1.146861 | 0.558051 | 0–100% | 0.01377 |
| Imputed | 0.5862 | 0.4435 | 5.31–100% | 0.089 | ||||
| 1042 | 0 | 97 | UK Clinical | Genotyped | 0.0000 | 0.1177 | 0–23.09% | 0.5 |
| Imputed | 0.0000 | 0.0965 | 0–18.93% | 0.5 | ||||
| 4482 | 0 | 616 | Clinical Pooled | Genotyped | 0.0854 | 0.0192 | 4.76–12.32% | 4.584e–06 |
| Imputed | 0.0617 | 0.0161 | 3.02–9.33% | 2.247e–05 | ||||
| 4482 | 0 | Clinical Cohort Meta- Analysis Random Effects Model | Genotyped I^2 = 21% |
0.1406 | 0.0420 | 5.82–22.31% | 0.284 | |
| Imputed I^2 = 30.2% |
0.0674 | 0.0382 | 0–14.23% | 0.078 |