Table 2C.
Pathologically confirmed cohorts
| Total: Cases & Controls (N) | Cases:P ath (N) | Cases: Clinical (N) | Cohort | Imputation Status: 107,447 Genotyped SNPs / 11,138,628 Imputed SNPs | Heritability | Standard Error | 95% Confidence Interval (Percentage Heritability) | P-value |
|---|---|---|---|---|---|---|---|---|
| 972 | 28 | 0 | N.EU Pathology Confirmed | Genotyped | 0.114253 | 0.385713 | 0–87.02% | 0.3866 |
| Imputed | 0.000001 | 0.296941 | 0–58.2% | 0.5 | ||||
| 1198 | 14 | 0 | S.EU Pathology Confirmed | Genotyped | 2.269129 | 0.726325 | 100% | 1.413e–06 |
| Imputed | 2.269129 | 0.601680 | 100% | 4.586e–07 | ||||
| 901 | 108 | 0 | US Pathology Confirmed | Genotyped | 0.0000 | 0.1076 | 0–21.09% | 0.5 |
| Imputed | 0.0000 | 0.0839 | 0–16.45% | 0.5 | ||||
| 1086 | 141 | 0 | UK Pathology Confirmed | Genotyped | 0.0545 | 0.0822 | 0–21.09% | 0.2514 |
| Imputed | 0.0100 | 0.0706 | 0–14.85% | 0.4467 | ||||
| 4168 | 291 | 0 | All Pathology Confirmed | Genotyped | 0.0050 | 0.0375 | 0–7.85% | 0.4467 |
| Imputed | 0.0580 | 0.0315 | 0–11.99% | 0.03102 | ||||
| 4168 | 291 | 0 | Path- Confirmed Cohort Meta- Analysis Random Effects Model | Genotyped I^2 = 68.7% |
0.1398 | 0.1615 | 0–45.62% | 0.3865 |
| Imputed I^2 = 78.6% |
0.1391 | 0.1584 | 0–44.95% | 0.3799 |