Figure 4. Reward responsive VTA units coordinate with replayed reward locations.
(A) The SPW-R triggered VTA local field potential (LFP) shows a delayed potential. Time 0 reflects the start of SPW-R events. (B) Incorporating this delay between the hippocampus and VTA, across replay events occurring at the forced reward sites, RR unit spikes preferentially coordinated with replayed reward locations compared to SPW-R replay content in general (p=0.048, chi = 3.9, Chi-square test) and compared to nonRR units (p=0.016, nonparametric permutation test). Error bars represent s.d. (C) Probability distribution of replayed spatial locations for replay events occurring at the forced reward sites on the spatial working memory (SWM) (1) and linear tasks (2) (10 cm bins), accumulated across recordings. Dashed boxes designate reward sites. (D,E) Distribution of replayed locations coinciding with RR unit spikes (D1,2) and nonRR unit spikes (E1,2) adjusting for the latency between SPW-R onset and the VTA delayed potential. The probability colorbar for the SWM task ranges from 0 to 0.04 and for the linear track ranges from 0 to 0.1.