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. Author manuscript; available in PMC: 2016 Nov 5.
Published in final edited form as: Cell. 2015 Nov 5;163(4):1011–1025. doi: 10.1016/j.cell.2015.10.025

Figure 1. The molecular taxonomy of primary prostate cancer.

Figure 1

Comprehensive molecular profiling of 333 primary prostate cancer samples revealed seven genomically distinct subtypes, defined (top to bottom) by ERG fusions (46%), ETV1/ETV4/FLI1 fusions or overexpression (8%, 4%, 1%, respectively), or by SPOP (11%), FOXA1 (3%), and IDH1 (1%) mutations. A subset of these subtypes was correlated with clusters computationally derived from the individual characterization platforms (somatic copy-number alterations, methylation, mRNA, microRNA, and protein levels from reverse phase protein arrays). The heatmap shows DNA copy-number for all cases, with chromosomes shown from left to right. Regions of loss are indicated by shades of blue, and gains by shades of red.

See also Figures S1, S2, S3, S4, S5, S6, S7, and Tables S1A, S1B, S1E, S2.