Table 4.
Factors associated with mortality at D28
| Dead D28 N = 276 |
Alive D28 N = 860 |
Non adjusted analysis | Adjusted analysis | |||
|---|---|---|---|---|---|---|
| Crude OR | p | Adjusted OR | P | |||
| ICU | ||||||
| With low refusal rate (HBA) | 121 (43.8) | 359 (41.7) | 1 | 0.54 | 1 | |
| With high refusal rate (LBA) | 155 (56.2) | 501 (58.3) | 1.09 (0.83–1.43) | 1.34 (0.92–1.95) | 0.12 | |
| Age (mean ± SD) | 67 ± 14 | 55 ± 19 | 1.04 (1.03–1.05) | <0.001 | ||
| Sex | ||||||
| Male (%) | 179 (65) | 489 (57) | 1 | 1 | ||
| Female (%) | 97 (35) | 371 (43) | 0.71 (0.54–0.95) | 0.02 | 0.66 (0.45–0.98) | 0.04 |
| Characteristics on proposal, n (%) | ||||||
| Shock | 134 (48.6) | 146 (17.0) | 4.73 (3.51–6.37) | <0.001 | 1.81 (1.21–2.72) | 0.004 |
| Catecholamine infusion | 82 (29.7) | 66 (7.7) | 5.21 (3.63–7.48) | <0.001 | ||
| Glasgow score | 9.8 ± 5.0 | 11.9 ± 4.1 | 0.90 (0.87–0.93) | <0.001 | ||
| Platelets count <50,000/dl | 11 (4.0) | 13 (1.5) | 2.94 (1.30–6.64) | 0.007 | ||
| Prothrombine time <30 % | 24 (8.7) | 14 (1.6) | 6.17 (3.14–12.11) | <0.001 | 2.65 (1.09–6.44) | 0.03 |
| Creatinine level >250 µmol/l | 46 (16.7) | 80 (9.3) | 2.19 (1.48–3.25) | <0.001 | ||
| Jaundice | 14 (5.1) | 22 (2.6) | 2.09 (1.05–4.15) | 0.03 | ||
| Mechanical ventilation (all setting) | 148 (53.6) | 328 (38.1) | 1.93 (1.46–2.54) | <0.001 | ||
| NIV | 15 (5.4) | 54 (6.3) | 0.87 (0.48–1.58) | 0.65 | ||
| Oxygen administration >10L/min | 67 (24.3) | 147 (17.1) | 1.59 (1.14–2.21) | 0.006 | ||
| Preexisting diseases | ||||||
| COPD | 15 (5.4) | 52 (6.0) | 0.93 (0.51–1.68) | 0.81 | ||
| Cardiac insufficiency | 22 (8.0) | 34 (3.9) | 2.20 (1.26–3.84) | 0.005 | ||
| Evolutive malignancy | 44 (15.9) | 105 (12.2) | 1.42 (0.97–2.08) | 0.07 | ||
| Cirrhosis | 26 (9.4) | 31 (3.6) | 2.89 (1.68–4.97) | <0.001 | ||
| Renal failure with ERT | 8 (2.9) | 20 (2.3) | 1.30 (0.56–2.98) | 0.54 | ||
| Mac Cabe score | ||||||
| 0 | 81 (31.4) | 493 (58.4) | 1 | 1 | ||
| 1 | 99 (38.4) | 265 (31.4) | 2.27 (1.64–3.16) | <0.001 | 1.56 (1.02–2.37) | 0.04 |
| 2 | 78 (30.2) | 86 (10.2) | 5.52 (3.75–8.12) | <0.001 | 3.66 (2.21–6.06) | <0.001 |
| SAPS2 | 62 ± 20 | 34 ± 16 | 1.08 (1.07–1.10) | <0.001 | 1.08 (1.06–1.09) | <0.001 |
NIV non invasive ventilation, ERT extra renal therapy