Table 1:
Molecolar Classa | A | B | D |
Functional groupb | 2f | 3 | 2d |
Active site | Serine | Zn2+ | Serine |
Prominent Enzyme | GES, SME, NMC, KPC | IMP, VIM, SPM, GIM, SIM, NDM | OXA |
ATM Hydrolysis | + | - | - |
EDTA Inhibition | - | + | - |
CLA Inhibition | ± | - | ± |
APBA Inhibition | + | - | - |
Most Common Bacteria | Enterobacteriaceae (rare reports in P. aeruginosa) | P. aeruginosa Enterobacteriaceae Acinetobacter spp. | Acinetobacter spp. |
ATM: aztreonam; APBA: 3′-Aminophenylboronic acid; EDTA: ethylene diamine tetra-acetic acid; CLA: clavulanic acid
Ambler classification.
Bush, Jacoby and Medeiros classification.