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. 2015 Oct;7(5):226–246.

Table 1:

General classification of carbapenemases

Molecolar Classa A B D
Functional groupb 2f 3 2d
Active site Serine Zn2+ Serine
Prominent Enzyme GES, SME, NMC, KPC IMP, VIM, SPM, GIM, SIM, NDM OXA
ATM Hydrolysis + - -
EDTA Inhibition - + -
CLA Inhibition ± - ±
APBA Inhibition + - -
Most Common Bacteria Enterobacteriaceae (rare reports in P. aeruginosa) P. aeruginosa Enterobacteriaceae Acinetobacter spp. Acinetobacter spp.

ATM: aztreonam; APBA: 3′-Aminophenylboronic acid; EDTA: ethylene diamine tetra-acetic acid; CLA: clavulanic acid

a

Ambler classification.

b

Bush, Jacoby and Medeiros classification.