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TM4SF3 induces invasion and migration of PCa cells. (A) LNCaP or (B) C81 cells were treated with either ethanol (−) or 1nM R1881 (+), or (C) PC-3 cells were transfected with control (C) or TM4SF3 (T) siRNA and infected with empty (E) or TM4SF3-His adenovirus (T), and monitored (A–C) for invasion and migration. Bar graphs represent averages of 3 independent experiments ± SDs. The Student's t test was performed to show statistical significance (P < .005), as indicated by asterisks.
