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GW4064 increased FGFR4 protein stability in a βKL-dependent manner. A, PMHs were transfected with either control or βKL siRNA and/or (B) expression plasmid for βKL, and then, 48 hours later, cells were treated with vehicle or GW4064 for 2 hours, and further treated with CHX for indicated times. FGFR4 and actin protein levels were measured by IB. In A, the FGFR4 band intensities relative to the 0-minute time point were plotted at the right.
