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. 2015 Oct 30;4(4):687–705. doi: 10.3390/cells4040687

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The Polycystins in Cell Migration. PC-1 and PC-2 are involved in different pathways and functional roles, among these they were reported to inhibit apoptosis, proliferation, and growth. Furthermore, they are known to regulate calcium homeostasis. All these processes were shown to be deregulated in ADPKD. Additional functions of the PCs more recently reported involve regulation of cell migration and tissue morphogenesis. The involvement of these last two functions in the disease remains unclear (see text) (a); schematic summary showing the cellular effects of the PCs in cell migration and front-rear polarity in wound-healing assays [5,6,8,74]. PC-1 regulates the actin and microtubular cystoskeleton and the turnover rates of FAs and AJs and affecting both the rates of cell migration and front-rear polarity (b); at a single cell level MDCKII cells appear asymmetrical, whereas overexpression of PC-1 induces elongation and cellular asymmetry with a polarized actin cytoskeleton (red) and the Golgi (green) re-positioned in front of the nucleus (blue) (c).