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(A) Block diagram of Hh precursor protein, with signal peptide (grey), signaling ligand (blue), and autocatalytic segment (green). (B) Conserved residues in the autocatalytic segment displayed by Logoplot (http://weblogo.berkeley.edu/logo.cgi). Solid line delineates the HINT domain; hashed line, the SRR region. Residues marked with red asterisks are required for cholesterolysis.
