Table 2.
Genetic alterations and overall survival in the initial TCGA cohort in months (mo). In the initial TCGA cohort (n = 279), individual genetic alterations associated with worse overall survival include TP53 and EGFR, consistent with previous studies. Notably, this analysis does not stratify the type of mutation (activating/amplification vs. loss-of-function/deletion vs. benign).
| Altered Median OS (mo) | WT Median OS (mo) | Log-Rank p-Value | |
|---|---|---|---|
| TP53 | 19.2 | 65.8 | 0.04 |
| FAT1 | 18.8 | 26.4 | 0.80 |
| CDKN2A | 17.2 | 52.3 | 0.24 |
| PIK3CA | 28.3 | 21.9 | 0.41 |
| NOTCH1 | 18.0 | 28.3 | 0.49 |
| CASP8 | 18.8 | 26.4 | 0.31 |
| EGFR | 17.2 | 30.0 | 0.03 |