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. 2015 Nov 10;7(4):2217–2235. doi: 10.3390/cancers7040887

Figure 6.

Figure 6

Significant differences were detected between types of viral integration sites. (a) Certain features in 7/8 categories were significantly different near HPV-18 integrations compared to HPV-16 (HPV-16 n = 382, HPV-18 n = 133); and (b) integrations in cervical tissue compared to those in head and neck cancers (HNC) (cervical n = 431, HNC n = 59). Regardless of window size or whether or not the number of genes was controlled for, gene expression, repeats and certain transcription factors differed significantly between HPV types (a) and tissues (b). (c) Significant differences between cervical cancer (n = 419) and W12 cell line (n = 28) integration sites. (d) Significant differences between HBV integration sites in HCC (n = 628) and tumor-adjacent tissues (n = 618). Significance was determined using a two-sided Mann–Whitney U-test with Bonferroni correction, α < 0.05. Comparisons using the gene constraint set are indicated with GC.