Figure 3.

The core structure of the Drosophila Hippo pathway. Hippo and Warts form the kinase cassette. Mats and Salvador function as an activator and a linker to promote the Hippo-mediated activation of Warts. Salvador harbors two WW domains and the SARAH domain. Unphosphorylated Yorkie co-operates with Scalloped to regulate the transcription of cell cycle-promoting and anti-apoptotic genes. When Yorkie is phosphorylated by Warts, Yorkie is recruited from the nucleus to the cytoplasm and undergoes degradation (small entities symbolize degradation). dRASSF blocks the interaction between Hippo and Salvador. Inset: dRASSF suppresses the cell overproliferation phenotype caused by the hippo mutant lacking the SARAH domain but cannot rescue the phenotype caused by the kinase-dead mutant.