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. Author manuscript; available in PMC: 2015 Dec 30.
Published in final edited form as: Inhal Toxicol. 2014 Oct;26(12):720–732. doi: 10.3109/08958378.2014.954654

Figure 5.

Figure 5

Resistance spot welding aerosols alter the levels of neurotransmitters and their metabolites in the hippocampus (HIP). Rats were exposed to LM or HM aerosols (25 mg/m3 × 4 h/day) by whole-body inhalation for 13 days. At 1-day post-exposure, the levels of NE, DA, 5-HT, DOPAC, HVA and 5-HIAA were measured by HPLC-EC. Following normalization to an internal standard (isoproterenol), the concentration of each compound was calculated as ng/mg total protein. The metabolite ratios, DOPAC/DA, HVA/DA, (DOPAC+HVA/DA) and 5-HIAA/DA were then calculated from the individual measures. The values are expressed as percent of air-exposed controls and graphical representations are mean±SE (n=4/group) for the low metal exposure experiments and (n=6/group) for the high metal exposure experiments. *Indicates significant change from corresponding air-exposed control (p<0.05). #Indicates significantly different from LM-exposed group.