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. Author manuscript; available in PMC: 2015 Dec 30.
Published in final edited form as: Am J Gastroenterol. 2015 Feb 3;110(2):223–263. doi: 10.1038/ajg.2014.435

Table 3.

GRADE (Grading of Recommendations Assessment, Development and Evaluation) system of evidence and strength of recommendation

High Further research is very unlikely to change our confidence in the estimate of effect.
Moderate Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low Any estimate of the effect is very uncertain.