Table 3.

Examples of HIF-1 target genes encoding metabolic enzymes (blue text), transporters (red text), and mitochondrial proteins (green text) involved in glucose metabolism

Gene	Encoded protein	References supporting regulation by HIF-1
ALDOA	Aldolase A	3, 16, 107
ALDOC	Aldolase C	3, 108
BNIP3	BNIP3	79, 83, 109
BNIP3L	BNIP3-like (NIX)	83, 109
CAR9	Carbonic anhydrase 9	19, 29
COX4I2	Cytochrome oxidase subunit 4-2	54
ENO1	Enolase 1	3, 16
ENO2	Enolase 2	83
GAPDH	Glyceraldehyde phosphate dehydrogenase	3, 107, 110
GPI	Glucose phosphate isomerase	18, 19, 111
HK1	Hexokinase 1	3
HK2	Hexokinase 2	3, 18, 19
LDHA	Lactate dehydrogenase A	3, 16, 112
miR210	MicroRNA-210	58, 59
PDK1	Pyruvate dehydrogenase kinase 1	55, 56
PDK3	Pyruvate dehydrogenase kinase 3	57
PFKFB3	6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	113
PFKFB4	6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	113
PFKL	Phosphofructokinase, liver	3, 19
PGAM1	Phosphoglycerate mutase 1	19
PGK1	Phosphoglycerate kinase 1	3, 107, 114
PGM1	Phosphoglucomutase 1	3, 83
PGM3	Phosphoglucomutase 3	83
SLC2A1	Glucose transporter 1	3, 107, 115
SLC2A3	Glucose transporter 3	3, 83
SLC9A1	Sodium-hydrogen exchanger 1	116
SLC16A3	Monocarboxylate transporter 4	18, 29, 117
TKT	Transketolase	118
TKTL2	Transketolase-like 2	118
TPI1	Triosephosphate isomerase	3, 119