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. Author manuscript; available in PMC: 2015 Dec 30.
Published in final edited form as: Curr Top Dev Biol. 2015 Feb 11;112:353–382. doi: 10.1016/bs.ctdb.2014.12.001

Figure 4.

Figure 4

Is there are conserved epithelial migratory program? Dissemination might be explained by a switch in the substrate of migration from adjacent cells to ECM. (A) Epithelial cells collectively migrate as an elongating bud during mammary branching morphogenesis. Within the multilayer, an individual epithelial cell (green; dark gray shade in the print version) can appear elongated and protrusive. (B) During Twist1-induced dissemination, a single epithelial cell (green; dark gray shade in the print version) migrates through the ECM with amoeboid morphology and extensive protrusions at the leading front.