Table 3.
Rate of breast cancer related to meningeal carcinomatosis in patients with bone and/or brain metastasis occurrence: 5 years (column A) and 10 years (column B) after surgery
| Column A: 5-year follow up | Column B: 10-year follow up | |||||||
|---|---|---|---|---|---|---|---|---|
| MC events | Patients | Person-years | Rate (per 100) | MC events | Patients | Person-years | Rate (per 100) | |
| Occurrence of bone metastasisa | ||||||||
| No | 2 | 1780 | 5434 | 0.037 (0.0092–0.147) | 3 | 1898 | 7770 | 0.039 (0.012–0.12) |
| Yes | 1 | 52 | 84 | 1.19 (0.168–0.85) | 3 | 87 | 177 | 1.69 (0.55–5.25) |
| (p < 0.001) | (p < 0.001) | |||||||
| Occurrence of brain metastasis | ||||||||
| No | 2 | 1792 | 5510 | 0.036 (0.0091–0.15) | 3 | 1912 | 7929 | 0.038 (0.012–0.12) |
| yes | 1 | 9 | 7 | 14.36 (2.02–101.93) | 3 | 15 | 18 | 16.58 (5.35–51.41) |
| (p < 0.001) | (p < 0.001) | |||||||
aPatients sum up to more than 1793 (5-year follow-up) or 1915 (10-year follow-up) because bone and brain metastases are time-dependent variables; thus, a single patient who developed metastasis during the follow up contributed to both levels (yes and no) of the variable