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. Author manuscript; available in PMC: 2015 Dec 30.
Published in final edited form as: ChemMedChem. 2011 Mar 15;6(5):759–764. doi: 10.1002/cmdc.201100026

Figure 3.

Figure 3

Views from the crystal structure of JMJD2A in complex with compound 13a (yellow sticks). The double-stranded β-helix (conserved in 2OG oxygenases) is in red. Residues that bind Fe(II) and 2OG are shown as green sticks, Ni(II), which replaces Fe(II) for crystallography, is shown as a green sphere. Other residues likely interacting with 13a are shown as blue sticks.