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Inhibition of the histone demethylase JMJD2E (100 nM) by bipyridyl compounds. IC50s represent the result of three independent experiments, where standard errors in the log(IC50) are less than 10 %. Ranking of binding strength by ESI-MS is as shown in Figure 3. All compounds were counter-screened against FDH at the same concentrations used for IC50 determinations, and inhibition of FDH was not observed under these conditions, implying that the compounds only inhibited JMJD2E.
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