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. 2015 Dec 29;16:1106. doi: 10.1186/s12864-015-2351-1

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© Wallqvist et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Yeast two-hybrid (Y2H) host-pathogen protein-protein interactions (PPIs). Using Y2H screens against whole human and murine proteome libraries, we identified 222 unique PPIs between 18 Francisella tularensis proteins and 183 human proteins (a) and 118 unique PPIs between 13 F. tularensis proteins and 113 murine proteins (b). Green nodes represent F. tularensis proteins, whereas pink and red nodes represent host proteins. Eleven F. tularensis proteins interacted with both hosts, and six of them participated in 21 conserved interactions (red edges), i.e., six F. tularensis proteins that interacted with both human proteins (red nodes in a) and their murine orthologs (red nodes in b)