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. 2015 Dec 29;16:1106. doi: 10.1186/s12864-015-2351-1

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© Wallqvist et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Fifty percent lethal dose (LD₅₀) estimation. Using the dose-response experiments, we estimated LD₅₀ values and 95 % confidence intervals for the wild-type strain and each of the mutant strains. The estimated wild-type LD₅₀ of 2.62 CFU, where CFU denote colony-forming units, agreed with previously estimated values for the wild-type F. tularensis subsp. tularensis Schu S4 strain. The estimated LD₅₀ values for ΔFTT0482c and ΔFTT1597 were higher than the wild-type value and outside its 95 % confidence intervals, whereas the LD₅₀ value estimated for ΔFTT1538c was above the wild-type value, although with overlapping confidence intervals. These results support the notion that ΔFTT0482c, ΔFTT1538c, and ΔFTT1597 attenuate F. tularensis virulence in this animal model