Table 2.
List of proteins selected for experimental yeast two-hybrid evaluation
| Group | Locus ID | Name | Description | Interactions | ||
|---|---|---|---|---|---|---|
| Human | Mouse | Common | ||||
| 1 | FTT0369c | DipA | Deficient in intracellular replication A | - | - | - |
| FTT0584 | - | Unknown | - | - | - | |
| FTT0901 | LpnA | Lipoprotein | - | 1 | - | |
| FTT0918 | FopC | Outer membrane lipoprotein | - | - | - | |
| FTT1103 | DsbA | Conserved hypothetical lipoprotein | - | - | - | |
| FTT1179 | BipA | GTP binding translational elongation factor Tu | 29 | - | - | |
| FTT1508c | RelA | GTP pyrophosphokinase | 3 | - | - | |
| FTT1726 | YegQ | Protease YegQ | - | - | - | |
| FTT1676 | - | Protein of unknown function, membrane protein | - | - | - | |
| FTT0356 | HtpG | Chaperone, heat shock protein HtpG, ATPase activity | 20 | 1 | 1 | |
| FTT0626 | Lon | Chaperone, ATP-dependent DNA-binding protease Lon | 2 | 2 | - | |
| FTT1769c | ClpB | Chaperone, ATP-dependent CLP protease ATP-binding subunit ClpB | - | - | - | |
| FTT1712c | IglC2 | Intracellular growth locus, subunit C | 43 | 33 | 1 | |
| FTT0068 | SodB | Superoxide dismutase | - | 12 | - | |
| FTT1707 | IglI2 | Uncharacterized protein | - | - | - | |
| 2 | FTT0013c | - | Protein of unknown function | - | - | - |
| FTT0295 | - | Hypothetical protein | - | - | - | |
| FTT0520 | - | Putative uncharacterized protein | - | - | - | |
| FTT0842 | - | Peptidoglycan-associated lipoprotein | 9 | 17 | - | |
| FTT0902 | - | Protein of unknown function | 8 | 1 | - | |
| FTT0975 | - | Protein of unknown function | - | - | - | |
| FTT1039 | DacB1 | d-Alanyl-d-alanine carboxypeptidase (penicillin-binding protein) family protein | - | - | - | |
| FTT1040 | - | Lipoprotein | - | - | - | |
| FTT1334c | - | Hypothetical protein | 1 | 1 | - | |
| FTT1402c | - | Protein of unknown function | - | - | - | |
| FTT1538c | - | Hypothetical protein | 25 | 22 | - | |
| FTT1549 | - | Protein of unknown function | - | - | - | |
| FTT1626c | - | Hypothetical protein | - | - | - | |
| FTT1688 | - | Aromatic amino acid HAAP transporter | - | - | - | |
| FTT1314c | PilE6 | Type IV pili fiber building block protein | 4 | - | - | |
| FTT1776c | - | Hypothetical protein | 2 | - | - | |
| 3 | FTT0086 | - | Conserved protein of unknown function | - | - | - |
| FTT0103c | - | Hypothetical protein | 2 | - | - | |
| FTT0792 | - | LPS locus | - | - | - | |
| FTT0889c | - | Type IV pili fiber building block protein | - | - | - | |
| FTT1530 | FadB/AcbP | Bifunctional 3-hydroxacyl-CoA dehydrogenase | - | - | - | |
| FTT1564 | - | Polyphosphate kinase | 9 | 6 | 1 | |
| 4 | FTT0018 | - | Secretion protein | 10 | - | - |
| FTT0296 | Pcp | Pyrrolidone-carboxylate peptidase | - | - | - | |
| FTT0482c | - | Lipoprotein | 32 | 14 | 11 | |
| FTT1029 | DacD | d-Alanyl-d-alanine carboxypeptidase (penicillin binding protein) family protein | 5 | 2 | 2 | |
| FTT1157c | - | Type IV pili lipoprotein | - | - | - | |
| FTT1242 | - | Hypothetical protein | - | - | - | |
| FTT1591 | VacJ | Lipoprotein | - | - | - | |
| FTT1746 | - | Peptidase | - | - | - | |
| 5 | FTT1597 | - | Putative uncharacterized protein | 16 | 6 | 6 |
| FTT0522 | - | Hypothetical protein, methyltransferase domain | - | - | - | |
| FTT0604 | - | Hypothetical protein, methyltransferase domain | - | - | - | |
| FTT0677c | - | Putative uncharacterized protein | 2 | - | - | |
Group 1, multiple virulence association evidences and evidence about attenuation in an animal model; group 2, multiple virulence association evidences; group 3, transposon mutant screening evidence only; group 4, predicted secretion evidence only; group 5, orthology evidence only