Table 5.
Enrichment of GO biological processes in host subnetworks
| Category | Term | Size | p-value | ||||
|---|---|---|---|---|---|---|---|
| ID | Description | N C | N M | pGO | pRp | pRn | |
| Cellular regulation | GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 7 | 4 | 6.4∙10-3 | 1.0∙10-4 | 1.5∙10-4 |
| GO:0045892 | Negative regulation of transcription, DNA-dependent | 11 | 6 | 0.0 | 0.0 | 1.3∙10-4 | |
| GO:0051090 | Regulation of sequence-specific DNA binding transcription factor activity | 6 | 4 | 1.1∙10-3 | 0.0 | 1.1∙10-4 | |
| GO:0051345 | Positive regulation of hydrolase activity | 8 | 5 | 4.0∙10-4 | 0.0 | 7.7∙10-5 | |
| GO:0051726 | Regulation of cell cycle | 9 | 4 | 6.0∙10-4 | 7.0∙10-4 | 1.1∙10-3 | |
| Cellular signaling | GO:0023052 | Signaling | 22 | 8 | 9.2∙10-3 | 0.0 | 1.1∙10-3 |
| GO:0007166 | Cell surface receptor signaling pathway | 15 | 5 | 3.4∙10-3 | 6.0∙10-4 | 1.8∙10-3 | |
| Cellular response | GO:0070887 | Cellular response to chemical stimulus | 17 | 7 | 0.0 | 0.0 | 4.0∙10-4 |
| GO:0006950 | Response to stress | 18 | 10 | 4.0∙10-3 | 0.0 | 4.5∙10-4 | |
| GO:0010033 | Response to organic substance | 17 | 8 | 0.0 | 0.0 | 4.6∙10-4 | |
| Protein modification | GO:0016567 | Protein ubiquitination | 9 | 4 | 0.0 | 1.0∙10-4 | 2.9∙10-5 |
| GO:0016310 | Phosphorylation | 10 | 5 | 9.7∙10-3 | 2.0∙10-4 | 1.1∙10-4 | |
N C, number of proteins in the largest connected component annotated with a given term; N M, number of proteins in the largest interaction module for a given term; pGO, probability of the same number of proteins as N C being annotated with a given GO term solely through a random selection; pRn, probability that a given number of proteins as N M are annotated with a given GO term solely through random selection in a random network that has the same degree distribution as the human network; pRp, probability that a given number of proteins as N M are annotated with a given GO term solely through random selection. This table contains only the largest statistically significant interaction module for each term; the complete list is available as supplementary information (Additional file 8: Table S6).