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Blockage of ASICs inhibits NLRP1 inflammasome activation induced by extracellular acidosis. Representative immunoreactive bands and statistical results showing PcTX1 attenuated acidosis-induced increase in the expression of NLRP1 (a), caspase-1 (b), ASC (c), IL-1β (d), and IL-18 (e). Data are expressed as means ± SEM. n = 6, # p < 0.05 and ##p < 0.01 vs control, *p < 0.05 and **p < 0.01 vs pH 6.5
