Table 2.
Genotype and allele frequencies of −308 G > A polymorphism of the TNF-α gene, adjusted for the presence of. H pylori in patients with normal gastric mucosa, gastritis and gastric cancer
| Normal (n = 40) | Chronic gastritis (n = 70) | Gastric cancer (n = 24) | ||||||
|---|---|---|---|---|---|---|---|---|
| Hp + (n: 03) | Hp - (n: 37) | Hp + (n: 47) | Hp - (n: 23) | OR (95 % CI), p | Hp + (n: 21) | Hp - (n: 03) | OR (95 % CI, p | |
| Genotypes | ||||||||
| G/G | 03 (100 %) | 30 (81 %) | 34 (72.3 %) | 18 (78.3 %) | 1.55 (0.48-4.98), 0.46 | 15 (71.4 %) | 02 (66.6 %) | 3.66 (0.48-27.85), 0.2 |
| G > A | – | 04 (10.9 %) | 09 (19.1 %) | 05 (21.7 %) | 03 (14.3 %) | 01 (33.4 %) | ||
| A/A | – | 03 (8.1 %) | 04 (8.6 %) | – | 03 (14.3 %) | – | ||
| Alleles | ||||||||
| G | 6 (100 %) | 64 (86.5 %) | 77 (82 %) | 41 (89 %) | 1.36 (0.61- 3.03), 0.55 | 33 (78.5 %) | 05 (83.3 %) | 1.84 (0.70- 4.81),021 |
| A | – | 10 (13.5 %) | 17 (18 %) | 05 (11 %) | 09 (21.5 %) | 01 (16.7 %) | ||
Hp: Helicobacter pylori; n: number of samples