Table 1.
Mouse strain | NOTCH3 expression levela | Age at onset NOTCH3 accumulationb |
---|---|---|
tgN3MUT 350 | 350 % | 6 weeks |
tgN3MUT 200 | 200 % | 3 months |
tgN3MUT 150 | 150 % | 5 months |
tgN3MUT 100 | 100 % | 12 months |
a mRNA NOTCH3 expression levels relative to endogenous mouse Notch3 expression levels b first sign of positive, granular NOTCH3 staining in brain vessels, as determined by an experienced neuropathologist (S.v.D)