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. 2015 Dec 29;3:89. doi: 10.1186/s40478-015-0268-1

Table 1.

The NOTCH3 RNA expression level correlates with the age at onset of cerebrovascular NOTCH3 protein accumulation

Mouse strain NOTCH3 expression levela Age at onset NOTCH3 accumulationb
tgN3MUT 350 350 % 6 weeks
tgN3MUT 200 200 % 3 months
tgN3MUT 150 150 % 5 months
tgN3MUT 100 100 % 12 months

a mRNA NOTCH3 expression levels relative to endogenous mouse Notch3 expression levels b first sign of positive, granular NOTCH3 staining in brain vessels, as determined by an experienced neuropathologist (S.v.D)