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. 2015 Jun 30;15(9):1337–1348. doi: 10.1517/14712598.2015.1057563

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© The Author(s). Published by Informa UK, Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Systemic delivery of modified mRNA for gene therapy. A. Diagram of formulating modified mRNA into a liposome-protamine-RNA (LPR) complex. B. Proliferation capacity of the surviving H460 cells after HSV-tk/GCV therapy, determined by clonogenic assay. C. Tumor growth inhibition of H460 non-small cell lung cancer after HSV-tk/GCV therapy by systemic delivery of modified mRNA in the LPR.

Adapted with permission from [61].
A. DOTAP: 1,2-Dioleoyl-3-trimethylammonium-propane; DSPE: 1,2-Distearoyl-phosphatidylethanolamine; LPR: Lipid/protamine/mRNA. C. Con: Control; GCV: Ganciclovir; HSV-tk: Herpes simplex virus-thymidine kinase; LPD: lipid/protamine/DNA; LPR: lipid/protamine/mRNA.