Table 4.
Demographics and Outcomes in Matched Intra-Abdominal Infections
| Variable | Infections without subsequent EAI | Infections with subsequent EAI | p value |
|---|---|---|---|
| Number | 938 | 469 | - |
| Age | 57.2±0.5 | 55.4±0.7 | 0.04 |
| APACHE II score (mean) | 15.2±0.2 | 15.2±0.3 | >0.2 |
| APACHE II score (median) | 15 (11–19) | 15 (10–20) | >0.2 |
| Males | 551 (58.7%) | 297 (54.1%) | >0.2 |
| Race | |||
| White | 799 (85.2%) | 460 (83.4%) | >0.2 |
| Black | 115 (12.3%) | 75 (13.7%) | |
| Other | 24 (2.5%) | 10 (1.8%) | |
| Location at onset of IAI | |||
| Home | 600 (64.0%) | 200 (36.4%) | <0.01 |
| Hospital ward | 277 (29.5%) | 260 (47.4%) | |
| ICU | 61 (6.5%) | 89 (16.2%) | |
| Days, admission to treatment | 1 (0–4) | 2 (0–8) | <0.01 |
| Maximum WBC (109 cells/L) | 16.0±0.3 | 16.0±0.4 | >0.2 |
| Maximum temperature (°C) | 37.8±0.0 | 38.0±0.0 | <0.01 |
| Diabetes mellitus | 217 (23.1%) | 106 (22.6%) | >0.2 |
| Dialysis dependence | 58 (6.2%) | 32 (6.8%) | >0.2 |
| Chronic corticosteroids | 375 (27.6%) | 110 (23.5%) | <0.01 |
| Cardiac disease | 212 (22.6%) | 108 (23.0%) | >0.2 |
| Ventilator dependence | 46 (4.9%) | 59 (12.6%) | <0.01 |
| Solid organ transplant | 217 (23.1%) | 80 (17.1%) | <0.01 |
| Most common pathogens (n) |
Candida spp./yeast 183 Enterococcus spp. 144 VRE 57 Bacteroides spp, 123 E. coli 84 Streptococcus spp. 69 Klebsiella spp. 50 S. aureus 48 MRSA 27 |
Candida spp./yeast 121 Enterococcus spp. 89 VRE 27 Bacteroides spp. 63 E. coli 59 Klebsiella spp. 27 Streptococcus spp. 26 S. aureus 23 MRSA 18 |
|
| Days of antimicrobial therapy (mean) | 11.9±0.3 | 18.6±1.1 | <0.01 |
| Days of antimicrobial therapy (median) | 11 (7–16) | 14 (9–22) | <0.01 |
| Hospital length of stay | 7 (4–12) | 25 (14–44) | <0.01 |
| In-hospital deaths | 84 (9.0%) | 70 (14.9%) | <0.01 |
EIA=extra-abdominal infection; IAI=intra-abdominal infection; ICU=intensive care unit; MRSA=methicillin-resistant Staphylococcus aureus; VRE=vancomycin-resistant enterococci; WBC=white blood cell count.