Table 2.
Associations Between Sex Hormones and Lipoprotein Fractions in Women, Beta-coefficient (P-value)
| SHBG | E2 | T | |
|---|---|---|---|
| log LDL (mg/dL) | |||
| Unadjusted | −0.03 (P = 0.09) | −0.05 (P = 0.06) | 0.01 (P = 0.92) |
| Model 1* | −0.08 (P = 0.20) | −0.03 (P = 0.31) | 0.03 (P = 0.65) |
| Model 1, and visceral adiposity (SD3) | −0.09 (P = 0.27) | −0.03 (P = 0.29) | 0.05 (P = 0.52) |
| Model 1, and hepatic density (HU) | −0.09 (P = 0.23) | −0.03 (P = 0.32) | 0.01 (P = 0.90) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | −0.09 (P = 0.33) | −0.03 (P = 0.38) | 0.0 (P = 0.97) |
| log HDL (nmol/L) | |||
| Unadjusted | 0.15 (0.06) | 0.0 (P = 0.81) | 0.04 (P = 0.68) |
| Model 1* | 0.13 (P = 0.12) | 0.01 (0.78) | 0.06 (P = 0.58) |
| Model 1, and visceral adiposity (SD3) | 0.0 (P = 0.93) | 0.02 (P = 0.57) | −0.01 (P = 0.91) |
| Model 1, and hepatic density (HU) | 0.21 (P = 0.05) | 0.04 (P = 0.38) | 0.09 (P = 0.45) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | 0.09 (P = 0.45) | 0.03 (P = 0.48) | 0.02 (P = 0.88) |
| log Triglycerides (mg/dL) | |||
| Unadjusted | −0.27 (P = 0.008) | 0.0 (P = 0.93) | −0.25 (P = 0.054) |
| Model 1* | −0.33 (P = 0.002) | 0.03 (P = 0.55) | −0.25 (P = 0.08) |
| Model 1, and visceral adiposity (SD3) | −0.16 (P = 0.20) | 0.02 (P = 0.74) | −0.14 (P = 0.27) |
| Model 1, and hepatic density (HU) | −0.24 (P = 0.05) | −0.03 (P = 0.53) | −0.20 (P = 0.11) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | −0.17 (P = 0.24) | −0.03 (P = 0.62) | −0.14 (P = 0.28) |
| log VLDL (nmol/L) | |||
| Unadjusted | −0.14 (P = 0.18) | −0.07 (P = 0.15) | −0.17 (P = 0.21) |
| Model 1* | −0.23 (P = 0.02) | −0.02 (P = 0.72) | −0.14 (P = 0.27) |
| Model 1, and visceral adiposity (SD3) | −0.20 (P = 0.13) | −0.03 (P = 0.56) | −0.09 (P = 0.49) |
| Model 1, and hepatic density (HU) | −0.52 (P = 0.0005) | −0.06 (P = 0.25) | −0.08 (P = 0.47) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | −0.15 (P = 0.33) | −0.06 (P = 0.31) | −0.09 (P = 0.51) |
| log LDL peak diameter (Å) | |||
| Unadjusted | 0.01 (P = 0.02) | 0.0 (P = 0.19) | 0.01 (P = 0.33) |
| Model 1* | 0.02 (P = 0.02) | 0.0 (P = 0.16) | 0.01 (P = 0.37) |
| Model 1, and visceral adiposity (SD3) | 0.01 (P = 0.03) | 0.0 (P = 0.22) | 0.01 (P = 0.76) |
| Model 1, and hepatic density (HU) | 0.02 (P = 0.01) | 0.0 (P = 0.63) | 0.01 (P = 0.38) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | 0.02 (P = 0.07) | 0.0 (P = 0.70) | 0.0 (P = 0.55) |
| LDL particle concentration (nmol/L) | |||
| Unadjusted | −0.13 (P = 0.01) | −0.02 (P = 0.39) | −0.06 (P = 0.36) |
| Model 1* | −0.16 (P = 0.002) | −0.02 (P = 0.52) | −0.04 (P = 0.51) |
| Model 1, and visceral adiposity (SD3) | −0.11 (P = 0.08) | −0.02 (P = 0.51) | 0.0 (P = 0.98) |
| Model 1, and hepatic density (HU) | −0.16 (P = 0.01) | −0.02 (P = 0.41) | −0.03 (P = 0.56) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | −0.11 (P = 0.12) | −0.02 (P = 0.54) | −0.03 (P = 0.64) |
| log Lp(a) (g/L) | |||
| Unadjusted | 0.12 (P = 0.60) | −0.11 (P = 0.29) | 0.24 (P = 0.43) |
| Model 1* | 0.05 (P = 0.83) | −0.07 (P = 0.56) | 0.28 (P = 0.37) |
| Model 1, and visceral adiposity (SD3) | 0.04 (P = 0.91) | −0.07 (P = 0.57) | 0.27 (P = 0.41) |
| Model 1, and hepatic density (HU) | 0.05 (P = 0.88) | −0.11 (P = 0.44) | 0.18 (P = 0.59) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | 0.0 (P = 0.99) | −0.11 (P = 0.45) | 0.10 (P = 0.78) |
| log HDL inflammatory index | |||
| Unadjusted | −0.13 (P = 0.44) | 0.03 (P = 0.70) | 0.15 (P = 0.49) |
| Model 1* | −0.15 (P = 0.34) | 0.07 (P = 0.39) | 0.18 (P = 0.37) |
| Model 1, and visceral adiposity (SD3) | 0.05 (P = 0.88) | 0.06 (P = 0.48) | 0.30 (P = 0.14) |
| Model 1, and hepatic density (HU) | −0.13 (P = 0.54) | 0.08 (P = 0.36) | 0.17 (P = 0.44) |
| Model 1, visceral adiposity, hepatic density, HOMA-IR | −0.04 (P = 0.87) | 0.10 (P = 0.29) | 0.31 (P = 0.17) |
*
Model 1 includes age (years), current smoking, and number of drinks per week.
Figures in bold are significant.