Table 1.
Clinical characteristics, laboratory parameters and GSTP1 analysis of studied groups.
| Variable | Patients (n=35) | Control (n=30) | P-value |
|---|---|---|---|
| Age (years) | 13.7±3.3 | 14.3±2.6 | 0.43 |
| Sex male, n (%) | 23(65.7) | 15(50) | 0.22 |
| Weight (Kg) | 36.22±10.82 | 57.46±12.34 | <0.0001 |
| Weight for age Z- score(WAZ) | −1.5±0.67 | 0.78±0.36 | <0.0001 |
| Height (Cm) | 142.06±14.6 | 156.6±11.28 | 0.001 |
| Height for age Z- score(HAZ) | −1.25±0.87 | −0.033±0.26 | <0.0001 |
| BMI | 17.9±3.8 | 23.1±2.5 | <0.0001 |
| BMI for age Z- score | −1.25±0.87 | −0.033±0.26 | <0.0001 |
| Puberty, n (%) | |||
| Normal | 15(42.9) | 30(100) | <0.0001 |
| Delayed | 20(57.1) | 0(0.0) | |
| Hb (gm/dl ) | 7.6±0.52 | 12.82±0.67 | <0.0001 |
| ALT (U/l) | 41.17±29.82 | 16.33±0.64 | <0.0001 |
| AST (U/l) | 42.57±32.53 | 27.54±3.67 | 0.727 |
| Blood urea (mg/dl) | 16.71±3.43 | 16.67±3.03 | 0.95 |
| Serum creatinine (mg/dl) | 0.52±0.12 | 0.55±0.15 | 0.33 |
| Serum Ca ( mg/dl) | 9.21±0.7 | 9.52±0.37 | 0.09 |
| Serum Ph ( mg/dl) | 3.02±0.45 | 2.82±0.49 | 0.1 |
| TALP (U/l) | 764.03±75.03 | 94.27±20.35 | <0.0001 |
| Serum Ferritin (ng/ml ) | 3329.6±2707.7 | 99.67±16.28 | <0.0001 |
| Osteocalcin ( ng/ml) | 13.07±2.87 | 4.63±1.13 | <0.0001 |
| BMD -LS (gm/cm2) | 0.57±0.20 | 1.53±0.47 | <0.0001 |
| Z - score -LS | −3.42±1.04 | 1.23±0.76 | <0.0001 |
| BMD haz Z- LS | −2.34±1.19 | 1.35±0.7 | <0.0001 |
| BMD -FN (gm/cm2) | 0.59±0.21 | 1.54±0.46 | <0.0001 |
| Z- score -FN | −2.39±0.96 | 1.24±0.72 | <0.0001 |
| BMDhaz Z- FN | −1.67±0.96 | 1.35±0.75 | <0.0001 |
| Allele frequency | |||
| A | 0.49 | 0.87 | <0.0001 |
| G | 0.51 | 0.13 | |
| Ile 105 Val allele, n (%) | |||
| Polymorphic (G allele ) | 27(77.1) | 6(20) | <0.0001 |
| Non-polymorphic (A allele ) | 8(22.9) | 24(80) | |
| Ile 105 Val genotype, n (%) | |||
| Wild homozygotes (AA) | 8 (22.9) | 24 (80) | <0.0001 |
| Heterozygotes (AG) | 18 (51.4) | 4 (13.3) | 0.001 |
| Homozygotes (GG) | 9 (25.7) | 2 (6.7) | 0.04 |
BMI; body mass index; Hb; hemoglobin; ALT; alanine aminotransferase; AST; aspartate aminotransferase; Ca; calcium; Ph; phosphorous; TALK; total alkaline phosphatase; BMD; bone mineral density; LS; lumbar spine; FN; femoral neck.