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. 2014 Oct 30;2(2):e959366. doi: 10.4161/2169074X.2014.959366

Figure 1.

Figure 1.

For figure legend, see page e959366-3. Figure 1. (See previous page). Formation of the 48S preinitiation complex. eIF1, 1A and 3 interact with the 40S ribosomal subunit. This then interacts with eIF5 and the ternary complex (eIF2-GTP-Met-tRNA) to form the 43S complex. In parallel, eIF4E and eIF4A are recruited by eIF4G to form the eIF4F complex. The availability of eIF4E is controlled by 4E-BP1, which in turn is regulated by phosphorylation by mTOR. The eIF4F complex binds to the cap on mRNA along with Poly(A)-binding protein (PABP) and eIF4B. PABP is regulated via interactions with 2 PABP proteins, PAIP1 and PAIP2. The 43S complex then binds close to the cap from where it can scan the mRNA for the start codon.