Table 3.
Associations of serum 25(OH)D levels with infectious composite events, cardiac composite events or all-cause mortality
| 25(OH)D ng/ml | Baseline 25(OH)D as Exposure | Time-Dependent 25(OH)D as Exposure | ||||||
|---|---|---|---|---|---|---|---|---|
| Composite of First Infectious Hospitalization or Infectious Death | ||||||||
| HR (95% CI), by Quartile | HR (95% CI), by Quartile | |||||||
| Q1 | Q2 | Q3 | Q4 | Q1 | Q2 | Q3 | Q4 | |
| <14 | 14–19 | 19–26 | >26 | <14 | 14–19 | 19–26 | >26 | |
| # of Events | 132 | 131 | 123 | 113 | 132 | 131 | 123 | 113 |
| Model 1 | 1.0 | 1.00 (0.77–1.30) | 0.96 (0.72–1.26) | 0.86 (0.64–1.16) | 1.0 | 0.79 (0.61–1.01) | 0.72 (0.55–0.94) | 0.66 (0.49–0.89) |
| Model 2 | 1.0 | 1.02 (0.78–1.34) | 1.08 (0.81–1.43) | 0.94 (0.69–1.28) | 1.0 | 0.79 (0.61–1.02) | 0.75 (0.57–0.98) | 0.72 (0.53–0.98) |
| Model 3 | 1.0 | 1.00 (0.77–1.30) | 0.95 (0.72–1.25) | 0.84 (0.62–1.14) | 1.0 | 0.79 (0.61–1.01) | 0.72 (0.55–0.94) | 0.66 (0.49–0.89) |
| Composite of First Cardiac Hospitalization or Cardiac Death | ||||||||
| # of Events | 133 | 138 | 127 | 116 | 133 | 138 | 127 | 116 |
| Model 1 | 1.0 | 1.05 (0.80–1.37) | 1.00 (0.75–1.33) | 0.94 (0.69–1.28) | 1.0 | 0.77 (0.59–0.99) | 0.74 (0.57–0.98) | 0.71 (0.53–0.96) |
| Model 2 | 1.0 | 1.06 (0.81–1.39) | 1.02 (0.77–1.37) | 0.99 (0.72–1.35) | 1.0 | 0.75 (0.58–0.98) | 0.73 (0.55–0.95) | 0.71 (0.52–0.96) |
| Model 3 | 1.0 | 1.06 (0.81–1.37) | 0.98 (0.74–1.31) | 0.89 (0.65–1.21) | 1.0 | 0.77 (0.59–1.00) | 0.74 (0.57–0.97) | 0.70 (0.52–0.94) |
| All-Cause Mortality | ||||||||
| # of Events | 167 | 151 | 139 | 125 | 167 | 151 | 139 | 125 |
| Model 1 | 1.0 | 0.88 (0.68–1.14) | 0.80 (0.61–1.05) | 0.72 (0.53–0.97) | 1.0 | 0.57 (0.45–0.73) | 0.50 (0.38–0.65) | 0.46 (0.34–0.62) |
| Model 2 | 1.0 | 0.93 (0.71–1.21) | 0.92 (0.69–1.22) | 0.84 (0.61–1.14) | 1.0 | 0.60 (0.47–0.77) | 0.55 (0.42–0.72) | 0.54 (0.40–0.74) |
| Model 3 | 1.0 | 0.88 (0.68–1.14) | 0.79 (0.61–1.04) | 0.70 (0.51–0.94) | 1.0 | 0.57 (0.45–0.73) | 0.50 (0.38–0.65) | 0.46 (0.34–0.62) |
Model 1: Adjusted for age, gender, race, diabetic status, history of cardiac disease, years of dialysis, smoking status, urea Kt/V, and dialysis membrane flux assignments, central catheter use, serum calcium, serum phosphorus, serum intact parathyroid hormone, serum 1,25-dihydroxyvitamin D, and serum FGF23.
Model 2: Adjusted for covariates in Model 1 plus serum albumin, serum high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α, and interferon-γ.
Model 3: Adjusted for covariates in Model 2 plus vitamin D analog administration.
Quartile 1 is the reference group in all models.