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. 2015 May 8;27(1):92–106. doi: 10.1681/ASN.2014121248

Figure 6.

Figure 6.

The effect of CGS21680 on renal IRI in HIF-2α−/− mice and WT littermates. CGS21680 (0.7 mg/kg) or vehicle (DMSO) was administered intraperitoneally at 24 hours before renal IR. Then the mice were subjected to 20 or 25 minutes of ischemia as described above. (A) Serum creatinine concentrations at 24 hours after reperfusion (n=8 per group). *P<0.05 versus vehicle-treated WT mice. (B) Survival of HIF-2α−/− and WT mice after renal ischemia (n=20 per group). CGS21680 treatment led to a significant survival advantage in WT but not HIF-2α−/− mice by Kaplan-Meier analysis (log-rank test, P<0.05 between CGS21680 and vehicle-treated WT mice in 25 min ischemia group; P>0.05 between CGS21680 and vehicle-treated HIF-2α−/− mice in both 20 and 25 min groups). (C) Representative PAS-stained sections in post-ischemic kidneys harvested at 24 hours. Original magnification, ×200. Abnormalities based on PAS-stained sections were graded and data are expressed as mean±SD from eight mice per group. *P<0.05 versus vehicle-treated WT mice. PAS, periodic acid–Schiff.