Table 1.
Proportion of lymphocyte subset and percentage of FasL+ cells in liver MNCs, splenocytes and thymocytes harvested from HIF-2α−/− mice and WT littermates
| NK1.1+TCRβ+ | NK1.1–TCRβ+ | NK1.1+TCRβ– | |
|---|---|---|---|
| Proportion of lymphocyte subset (% means±SD) | |||
| HIF-2α−/− liver MNCs | 5.8±1.3a | 21.8±4.2a | 15.7±4.3 |
| WT liver MNCs | 11.2±2.7 | 37.7±5.7 | 17.6±5.1 |
| HIF-2α−/− splenocytes | 1.1±0.3a | 31.2±4.8a | 8.9±2.5 |
| WT splenocytes | 1.9±0.4 | 45.9±6.8 | 7.9±2.6 |
| HIF-2α−/− thymocytes | 0.66±0.11 | 13.6±3.4 | |
| WT thymocytes | 0.65±0.13 | 14.1±3.1 | |
| % FasL+ cells (means±SD) | |||
| HIF-2α−/− liver MNCs | 26.6±10.9a | 4.6±1.3 | 3.3±1.2 |
| WT liver MNCs | 6.8±2.1 | 4.9±1.6 | 3.5±1.6 |
| HIF-2α−/− splenocytes | 22.8±8.6a | 0.26±0.11 | 0.89±0.24 |
| WT splenocytes | 4.5±1.4 | 0.21±0.12 | 0.88±0.32 |
| HIF-2α−/− thymocytes | 2.3±0.9 | 0.79±0.24 | |
| WT thymocytes | 2.2±1.1 | 0.76±0.23 |
Values represent mean±SD of six mice of each group.
a
P<0.05 by t test compared with the values of WT controls, respectively.