Table 2.

Hazard ratio (multivariate models) for graft failure according to renal allograft histology, renal function, and proteinuria at time of biopsy, adjusted for donor age and time after transplantation in Cohort 1 (n=1335 indication biopsies)

	Parameter	Adjusted Hazard Ratio (95% CI)	P Value
Model 1: Without proteinuria
eGFR at time of biopsy	30–45 versus >45 mL/min per m2	1.48 (0.50–4.40)	0.48
	15–30 versus >45 mL/min per m2	4.21 (1.53–11.6)	<0.01
	<15 versus >45 mL/min per m2	9.41 (3.37–26.3)	<0.001
Microcirculation inflammation	g+ptc ≥2 versus <2	1.45 (1.03–2.04)	0.03
IF/TA grade	Banff grade 1 versus 0	1.72 (1.19–2.50)	0.004
	Banff grade 2–3 versus 0	3.44 (2.34–5.05)	<0.001
Transplant glomerulopathy	Banff grade 1 versus 0	1.24 (0.69–2.22)	0.48
	Banff grade 2–3 versus 0	2.54 (1.54–4.18)	<0.001
De novo/recurrent glomerular disease	Present versus absent	1.59 (0.99–2.56)	0.06
Polyomavirus associated nephropathy	Present versus absent	5.84 (3.22–10.6)	<0.001
Model 2: With proteinuria
Proteinuria at time of biopsy	0.3–1.0 versus <0.3 g/24 h	1.14 (0.81–1.60)	0.50
	1.0–3.0 versus <0.3 g/24 h	2.17 (1.49–3.18)	<0.001
	>3.0 versus <0.3 g/24 h	3.01 (1.75–5.18)	<0.001
eGFR at time of biopsy	30–45 versus >45 mL/min per m2	1.76 (0.59–5.30)	0.31
	15–30 versus >45 mL/min per m2	5.53 (1.99–15.4)	0.001
	<15 versus >45 mL/min per m2	11.7 (4.17–33.0)	<0.001
Microcirculation inflammation	g+ptc ≥2 versus <2	1.36 (0.97–1.91)	0.07
IF/TA grade	Banff grade 1 versus 0	1.82 (1.25–2.64)	0.002
	Banff grade 2–3 versus 0	3.45 (2.34–5.07)	<0.001
Transplant glomerulopathy	Banff grade 1 versus 0	1.00 (0.55–1.82)	0.99
	Banff grade 2–3 versus 0	1.83 (1.11–3.04)	0.02
De novo/recurrent glomerular disease	Present versus absent	1.35 (0.84–2.19)	0.22
Polyomavirus associated nephropathy	Present versus absent	5.51 (3.06–9.92)	<0.001

g, glomerulitis; ptc, peritubular capillaritis; IF/TA, interstitial fibrosis/tubular atrophy.