Table 3.

Predictive performance of 24-hour proteinuria for graft failure in ROC analysis in Cohort 1

	AUC	P Value	Sensitivity	Specificity	PPV	NPV
Graft failure at 5 years after proteinuria measurement
3 months post-transplant (n=914)
Proteinuria >1.0 g/24 h	0.64 (0.57–0.70)	<0.001	10.1% (4.47–19.0%)	95.3% (93.7–96.7%)	19.5%	91.2%
Proteinuria >3.0 g/24 h			5.06% (1.40–12.5%)	99.5% (98.8–99.9%)	50.0%	91.1%
1 year post-transplant (n=778)
Proteinuria >1.0 g/24 h	0.73 (0.66–0.80)	<0.001	16.4% (8.15–28.1%)	95.5% (93.8–96.9%)	26.3%	92.6%
Proteinuria >3.0 g/24 h			4.92% (1.03–13.7%)	99.6% (98.8–99.9%)	60.0%	91.9%
2 years post-transplant (n=731)
Proteinuria >1.0 g/24 h	0.71 (0.63–0.80)	<0.001	20.0% (10.4–33.0%)	95.6% (93.7–97.0%)	30.6%	93.1%
Proteinuria >3.0 g/24 h			5.45% (1.14–15.1%)	99.4% (98.5–99.8%)	50.0%	92.2%
5 years post-transplant (n=637)
Proteinuria >1.0 g/24 h	0.77 (0.70–0.83)	<0.001	28.4% (18.0–40.7%)	96.4% (94.5–97.7%)	61.3%	91.0%
Proteinuria >3.0 g/24 h			4.48% (0.93–12.5%)	99.8% (99.0–100%)	100%	88.6%
Graft failure at 5 years after indication biopsy
All biopsies (n=1335)
Proteinuria >1.0 g/24 h	0.66 (0.63–0.69)	<0.001	31.7% (27.0–36.7%)	86.1% (83.5–88.4%)	51.5%	73.2%
Proteinuria >3.0 g/24 h			7.32% (4.88–10.5%)	97.9% (96.6–98.8%)	63.0%	69.6%
Biopsies <3 months post-transplant (n=752)
Proteinuria >1.0 g/24 h	0.62 (0.57–0.67)	<0.001	25.9% (19.4–33.3%)	87.2% (84.0–89.9%)	38.7%	78.4%
Proteinuria >3.0 g/24 h			2.41% (0.66–6.05%)	98.3% (96.7–99.2%)	35.7%	75.8%
Biopsies > 3 months post-transplant (n=583)
Proteinuria >1.0 g/24 h	0.71 (0.67–0.76)	<0.001	36.5% (29.8–43.5%)	84.8% (80.0–88.7%)	63.6%	65.1%
Proteinuria >3.0 g/24 h			10.8% (6.92–16.0%)	97.2% (94.5–98.8%)	75.0%	60.5%

PPV, positive predictive value; NPV, negative predictive value.