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. Author manuscript; available in PMC: 2015 Dec 30.
Published in final edited form as: Psychopharmacology (Berl). 2013 Aug 11;231(1):257–267. doi: 10.1007/s00213-013-3228-0

Figure 5.

Figure 5

MT1 Melatonin Receptor Deletion Abrogates METH-Induced Locomotor Sensitization in C57 Mice. Ordinates represent locomotor activity as distance traveled in 5-min intervals as a function of time (abscissae). Mice were pretreated at either ZT 5–7 (A and B) or ZT 19–21 (C and D) with VEH (○) or METH (1.2 mg/kg, i.p.) (■) on Day/Night 1, then challenged with METH on Day/Night 9. Insets show total distance traveled (m) from −55 to 0 min and from 5–60 min. Treatments were administered as denoted by arrows under the abscissae. * p < 0.05 compared to VEH.