. Author manuscript; available in PMC: 2016 Jul 27.

Published in final edited form as: ACS Infect Dis. 2015 Jul 27;1(8):340–349. doi: 10.1021/acsinfecdis.5b00070

Table 1.

Results of Activity Assays (IC₅₀, CC₅₀, EC₅₀, Therapeutic Index (TI)) for Selected Compounds, with the WNV MTase

compound ID (NSC)	IC₅₀ N7 (µM), no CHAPS	IC₅₀ N7 (µM), with CHAPS	IC₅₀ 2′-O (µM), with CHAPS	CC₅₀ (µM)	EC₅₀ (µM)	TI
12155	1.4	0.87	3.0	49	1.0	49
371880	63	nd^a	72	212	nd
372295	62	nd	57	126	nd
23217	15.7	>300	7.4	236	nd
125910	7.6	17.6	3.2	177	2.6	68
293161	13.2	31	54.6	25	nd

nd, not determined.