Table 1. Clinical and epidemiologic patient characteristics from an Elizabethkingia meningoseptica outbreak in an adult critical care unit, West London, UK, 2012–2013*.
Patient no. | Age, y/sex | Admission category | Date of E. m. acquisition | Hospital day of acquisition | Sample type† | Antimicrobial therapy immediately before E. m. acquisition | E. m. treatment regimen | Clinical outcome | PFGE designation |
---|---|---|---|---|---|---|---|---|---|
1 | 29/M | Trauma | 2012 Jan 12 | 35 | Respiratory | None | None | Discharged | NA |
2 | 45/F | Medical | 2012 Feb 27 | 9 | Respiratory | TZP | None | Discharged | EZ1 |
3 | 58/M | Medical | 2012 Mar 2 | 22 | Respiratory | MEM + CAS | None | Discharged | EZ1 |
4 | 34/M | Trauma | 2012 Mar 10 | 18 | Respiratory | TZP | None | Discharged | NA |
5‡ | 28/M | Trauma | 2012 Mar 20 | 15 | Screening | MEM | TGC | Discharged | EZ2 |
6 | 64/M | Surgical | 2012 Mar 22 | 4 | Respiratory | None | None | Discharged | NA |
7‡ | 77/M | Medical | 2012 Mar 28 | 10 | Screening | MEM + MTZ | None | Discharged | EZ1 |
8 | 69/M | Trauma | 2012 Apr 18 | 11 | Screening | MEM | None | Discharged | NA |
9‡ | 35/F | Trauma | 2012 May 21 | 19 | Screening | TZP + AFG | TMP/SXT | Discharged | EZ2 |
10‡§ | 35/F | Surgical | 2012 Jul 16 | 14 | Respiratory | MEM | TMP/SXT | Discharged | NA |
11‡§ | 60/F | Medical | 2012 Jul 21 | 22 | Respiratory | None | None | Died | EZ1 |
12 | 55/M | Surgical | 2012 Jul 27 | 14 | Respiratory | TZP + VAN | None | Died | EZ1 |
13 | 43/M | Trauma | 2012 Sep 13 | 6 | Screening | MEM + MTZ | None | Discharged | NA |
14 | 40/M | Trauma | 2012 Dec 27 | 13 | Respiratory | MEM + VAN | None | Discharged | NA |
15 | 40/F | Medical | 2013 Jan 3 | 31 | Blood culture | MEM + MTZ | TGC | Died | NA |
16‡ | 23/M | Trauma | 2013 Jan 14 | 13 | Respiratory | None | None | Discharged | EZ1 |
17 | 57/M | Trauma | 2013 Jan 14 | 13 | Respiratory | TZP + FCA | None | Discharged | NA |
18‡§ | 19/M | Trauma | 2013 Mar 26 | 25 | Respiratory | TZP + MTZ | None | Discharged | NA |
19‡ | 70/M | Vascular | 2013 Apr 8 | 11 | Respiratory | MEM + FCA | TGC | Discharged | Unique |
20‡§ | 61/F | Trauma | 2013 Apr 27 | 11 | Respiratory | MEM | TGC | Died | Unique |
21‡§ | 43/M | Surgical | 2013 May 1 | 12 | Respiratory | MEM +AFG | None | Discharged | NA |
22‡ | 17/M | Trauma | 2013 May 22 | 28 | Screening | MEM + MTZ | None | Discharged | EZ3 |
23§ | 60/M | Medical | 2013 May 30 | 13 | Respiratory | TZP + FCA | None | Died | NA |
24‡§ | 75/F | Trauma | 2013 Jun 21 | 13 | Respiratory | TZP | TGC | Discharged | NA |
25 | 75/M | Trauma | 2013 Jun 22 | 12 | Respiratory | MEM + VAN | None | Discharged | NA |
26 | 77/F | Medical | 2013 Aug 2 | 22 | Respiratory | TZP | TMP/SXT | Discharged | EZ1 |
27 | 31/M | Trauma | 2013 Sep 15 | 26 | Respiratory | MEM + VAN | TGC | Discharged | NA |
28‡§ | 83/M | Surgical | 2013 Sep 15 | 28 | Respiratory | TZP + FCA | TMP/SXT | Discharged | NA |
29‡§ | 32/M | Trauma | 2013 Oct 10 | 11 | Respiratory | TZP + VAN | TMP/SXT | Discharged | NA |
30 | 48/M | Trauma | 2013 Oct 29 | 34 | Respiratory | TZP + VAN | None | Discharged | NA |
31¶ | 34/F | Trauma | 2014 Apr 12 | 1 | Screening | None | None | Discharged | Unique |
*AFG, anidulofungin; CAS, caspofungin; Dis, discharged; E. m., E. meningoseptica; FCA, fluconazole; MEM, meropenem; MTZ, metronidazole; NA, isolate unrecoverable for PFGE analysis; PFGE, pulsed-field gel electrophoresis; TGC, tigecycline; TMP/SXT, trimethoprim/sulfamethoxazole; TZP, piperacillin/tazobactam; VAN, vancomycin; TGC, tigecycline; AFG, anidulofungin. †Respiratory sample types included nondirected bronchoalveolar lavage or endotracheal suction. Cross-infection screens comprise throat, rectum, nose, and groin swab specimens. ‡Patients in whom no other pathogen was identified in the 7 days before or after isolation of E. meningoseptica. §Patients in whom chest radiography demonstrated new-onset signs consistent with a pneumonic process in the 48 hours before and after E. meningoseptica isolation. ¶Postoutbreak infection.