Table 2. Antibody titers to influenza A/Anhui/1/2013(H7N9) in an anonymized population serosurvey, Lower Mainland, British Columbia, Canada, May 2013*.
Age group, y | No. patients† | Median age, y | % Female | Mean GMT (95% CI)‡ | No. (%, 95% CI)§ |
|
---|---|---|---|---|---|---|
With titer >10 | With titer >20 | |||||
<10 | 49 | 4 | 47 | 5 | 0 | 0 |
10–19 | 48 | 16 | 67 | 5 | 0 | 0 |
20–29 | 49 | 27 | 69 | 5 | 0 | 0 |
30–39 | 50 | 34 | 90 | 5 | 0 | 0 |
40–49 | 50 | 46 | 60 | 5 | 0 | 0 |
50–59 | 49 | 55 | 49 | 5 | 0 | 0 |
60–69 | 50 | 65.5 | 56 | 5.3 (4.9–5.7) | 3 (6.0, 0.0–12.6) | 1 (2.0, 0–5.9)¶ |
70–79 | 50 | 75 | 42 | 5 | 0 | 0 |
80–89 | 50 | 83 | 40 | 5.4 (5–5.9) | 4 (8.0, 0.5–15.5) | 1 (2.0, 0–5.9)¶ |
>90 |
51 |
92 |
73 |
5.3 (4.9–5.6) |
3 (5.9, 0.0–12.4) |
1 (2.0, 0–5.8)¶ |
All | 496 | 50 | 59 | 5.1 (5–5.2) | 10 (0.9, 0.2–1.7)# | 3 (0.3, −0.1 to 0.7)# |
*Titers were measured by hemagglutination inhibition assay by using horse erythrocytes as previously described (6); assays were conducted at the National Microbiology Laboratory, Canada’s influenza reference laboratory in July 2013. GMT, geometric mean titer. †Serum samples were collected in May 2013; 5 samples had insufficient serum and were excluded from the analyses (8). ‡Titers were assessed in duplicate. Titers <10 were assigned a value of 5. GMT of duplicate titers derived as individual titers and group GMTs derived by age and overall. §No patients had a titer >40. ¶Further assessed by microneutralization (MN) assay, according to procedures described by the Centers for Disease Control and Prevention (Atlanta, GA, USA); available by request. MN titers for all 3 samples were <10. #Age-standardized (direct method) to the 2013 Fraser Valley and Greater Vancouver, British Columbia, Canada, population projections (BC Stats, 2013: http://www.bcstats.gov.bc.ca/StatisticsBySubject/Demography/PopulationProjections.aspx).