Table 3. Intravenous sodium thiosulfate dosing recommendations based on pharmacokinetic simulations (adapted from Singh et al114).
| Number of hemodialysis sessions per week | 3 | 3 | 4 | 5 | 5 | 6 | Continuous renal replacement therapy | Continuous renal replacement therapy |
|---|---|---|---|---|---|---|---|---|
| Blood flow rate (ml/min) | 400 | 250 | 400 | 400 | 400 | 400 | 100 | 100 |
| Dialysis flow rate (ml/min) | 800 | 500 | 800 | 800 | 800 | 800 | 35 | 50 |
| Hemodialysis session duration (hours) | 4 | 4 | 3 | 2.5 | 8 | 2 | Continuous | Continuous |
| Sodium thiosulfate dose per hemodialysis session (g) | 25 | 24 | 22 | 18 | 24 | 16 | 24, daily | 35, daily |
| Weekly sodium thiosulfate dose (g) | 75 | 72 | 88 | 90 | 120 | 96 | 168 | 245 |